Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Naturally Acquired Immunity versus Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: A Retrospective Observational Study (2022)

Peer-Reviewed Study · Gazit S, Shlezinger R, Perez G, et al. · April 5, 2022

Israeli Maccabi retrospective cohort during the Delta period: previously infected, unvaccinated people had substantially lower reinfection risk than twice-vaccinated, never-infected people; symptomatic disease and hospitalization were rare in both groups (8 hospitalizations, all in the vaccinated group; zero deaths).

SARS-CoV-2-naive vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected

Clin Infect Dis 2022;75(1):e545-e551 (PubMed abstract)

Israeli Maccabi retrospective cohort during the Delta period: previously infected, unvaccinated people had substantially lower reinfection risk than twice-vaccinated, never-infected people; symptomatic disease and hospitalization were rare in both groups (8 hospitalizations, all in the vaccinated group; zero deaths). PMID 35380632. Observational Delta-era design; the 13-fold figure is for documented infection, not severe disease, and the authors note confounding and behavior differences as limitations.

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