Impact of the resumption of proactive recommendation of HPV vaccination on HPV vaccination rates in Japan (VENUS study) (2025)

Peer-Reviewed Study · Sazawa M, et al. (BMJ Public Health 2025;3:e000982) · December 17, 2025

States why the suspension ended: the MHLW Advisory Committee 'confirmed that there were no particular concerns regarding the safety of the vaccines' and that efficacy outweighed risks; MHLW decided in November 2021 to resume proactive recommendation from April 2022, with a catch-up program for the missed cohorts (April 2022 – March 2025). First-dose rates jumped 53% in April 2022 but remained far below WHO targets.

In April 2022, the Japanese government resumed proactive recommendations for routine HPV vaccination after an 8-year suspension and initiated a catch-up vaccination programme.

States why the suspension ended: the MHLW Advisory Committee 'confirmed that there were no particular concerns regarding the safety of the vaccines' and that efficacy outweighed risks; MHLW decided in November 2021 to resume proactive recommendation from April 2022, with a catch-up program for the missed cohorts (April 2022 – March 2025). First-dose rates jumped 53% in April 2022 but remained far below WHO targets.

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