Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial (2001)

Peer-Reviewed Study · Martin B. Keller et al. · July 2001

Keller et al. reported an eight-week double-blind randomized trial of 275 adolescents and concluded that paroxetine was generally well tolerated and effective. Adverse-effect withdrawal rates were 9.7% for paroxetine, 6.9% for placebo, and 31.5% for imipramine.

Paroxetine is generally well tolerated and effective for major depression in adolescents.

Keller et al. reported an eight-week double-blind randomized trial of 275 adolescents and concluded that paroxetine was generally well tolerated and effective. Adverse-effect withdrawal rates were 9.7% for paroxetine, 6.9% for placebo, and 31.5% for imipramine. Original Study 329 report; industry support and editorial assistance were disclosed. The paper was not retracted. Its conclusion conflicts with the later independent RIAT reanalysis.

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