Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies (1998)

Peer-Reviewed Study · Jason Lazarou, Bruce H. Pomeranz, and Paul N. Corey · April 15, 1998

The meta-analysis estimated 106,000 fatal hospital adverse drug reactions in 1994, with a 95% range of 76,000-137,000, from a fatal incidence of 0.32%. It excluded administration errors, noncompliance, overdose, drug abuse, therapeutic failures, and possible ADRs.

Of 153, we selected 39 prospective studies from US hospitals.

The meta-analysis estimated 106,000 fatal hospital adverse drug reactions in 1994, with a 95% range of 76,000-137,000, from a fatal incidence of 0.32%. It excluded administration errors, noncompliance, overdose, drug abuse, therapeutic failures, and possible ADRs. This was a hospital-based extrapolation, not a current all-cause outpatient mortality count.

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