The 1991 document that made hepatitis B vaccine part of routine infant schedules. States infants infected perinatally have a 90% risk of chronic infection and up to 25% will die of chronic liver disease; children of HBV-infected mothers remain at high risk of horizontal (person-to-person) transmission during the first 5 years of life; risk-group-only vaccination failed (acute hepatitis B rose 37% from 1979 to 1989). NOTE: the book's '10 to 20 percent' transmission figure misrepresents this document — ACIP's range is 10% to 85% depending on maternal HBeAg status.
The risk of perinatal HBV infection among infants born to HBV-infected mothers ranges from 10% to 85%, depending on each mother's hepatitis B e antigen (HBeAg) status
The 1991 document that made hepatitis B vaccine part of routine infant schedules. States infants infected perinatally have a 90% risk of chronic infection and up to 25% will die of chronic liver disease; children of HBV-infected mothers remain at high risk of horizontal (person-to-person) transmission during the first 5 years of life; risk-group-only vaccination failed (acute hepatitis B rose 37% from 1979 to 1989). NOTE: the book's '10 to 20 percent' transmission figure misrepresents this document — ACIP's range is 10% to 85% depending on maternal HBeAg status.