Treatment for Pediatric Gender Dysphoria: Review of Evidence and Best Practices—Executive Summary (2025)

Government Record · U.S. Department of Health and Human Services · November 19, 2025

HHS’s umbrella review assessed 17 systematic reviews and rated the overall evidence for psychological outcomes, quality of life, regret, and long-term health as very low quality. It is an HHS review commissioned under EO 14187, not a clinical practice guideline.

The umbrella review found that the overall quality of evidence concerning the effects of any intervention on psychological outcomes, quality of life, regret, or long-term health, is very low.

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HHS’s umbrella review assessed 17 systematic reviews and rated the overall evidence for psychological outcomes, quality of life, regret, and long-term health as very low quality. It is an HHS review commissioned under EO 14187, not a clinical practice guideline. The review was performed by HHS under the administration that ordered the underlying policy review; it is not independent confirmation of either HHS policy or a medical society guideline.

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