Estradiol labeling: not indicated for pediatric patients; no pediatric clinical studies – confirming cross-sex hormone use in minors is off-label for both sexes.
Estradiol is not indicated for use in pediatric patients. Clinical studies have not been conducted in the pediatric population.
8.4 Pediatric Use
Estradiol labeling: not indicated for pediatric patients; no pediatric clinical studies – confirming cross-sex hormone use in minors is off-label for both sexes.