2017 Endocrine Society guideline recommending GnRH-agonist suppression at Tanner 2, cross-sex hormones around 16, surgery typically 18+. Uses GRADE; most recommendations rest on low or very-low quality evidence (explicitly graded). Two corrigenda issued 2018.
We recommend that clinicians begin pubertal hormone suppression after girls and boys first exhibit physical changes of puberty (Tanner stages G2/B2).
web page (guideline recommendation 1.4 area)
2017 Endocrine Society guideline recommending GnRH-agonist suppression at Tanner 2, cross-sex hormones around 16, surgery typically 18+. Uses GRADE; most recommendations rest on low or very-low quality evidence (explicitly graded). Two corrigenda issued 2018. Society guideline reviewing literature its members produce – Cass Review's guideline appraisal found limited editorial independence across such guidelines.