Keller et al. reported an eight-week double-blind randomized trial of 275 adolescents and concluded that paroxetine was generally well tolerated and effective. Adverse-effect withdrawal rates were 9.7% for paroxetine, 6.9% for placebo, and 31.5% for imipramine.
Paroxetine is generally well tolerated and effective for major depression in adolescents.
Keller et al. reported an eight-week double-blind randomized trial of 275 adolescents and concluded that paroxetine was generally well tolerated and effective. Adverse-effect withdrawal rates were 9.7% for paroxetine, 6.9% for placebo, and 31.5% for imipramine. Original Study 329 report; industry support and editorial assistance were disclosed. The paper was not retracted. Its conclusion conflicts with the later independent RIAT reanalysis.